Excitation and sensitization of nociceptors by bradykinin: what do we know?
K Mizumura, T Sugiura, K Katanosaka… - Experimental brain …, 2009 - Springer
K Mizumura, T Sugiura, K Katanosaka, RK Banik, Y Kozaki
Experimental brain research, 2009•SpringerBradykinin is an endogenous nonapeptide known to induce pain and hyperalgesia to heat
and mechanical stimulation. Correspondingly, it excites nociceptors in various tissues and
sensitizes them to heat, whereas sensitizing effect on the mechanical response of
nociceptors is not well established. Protein kinase C and TRPV1 contribute to the sensitizing
mechanism of bradykinin to heat. In addition, TRPA1 and other ion channels appear to
contribute to excitation caused by bradykinin. Finally, prostaglandins sensitize bradykinin …
and mechanical stimulation. Correspondingly, it excites nociceptors in various tissues and
sensitizes them to heat, whereas sensitizing effect on the mechanical response of
nociceptors is not well established. Protein kinase C and TRPV1 contribute to the sensitizing
mechanism of bradykinin to heat. In addition, TRPA1 and other ion channels appear to
contribute to excitation caused by bradykinin. Finally, prostaglandins sensitize bradykinin …
Abstract
Bradykinin is an endogenous nonapeptide known to induce pain and hyperalgesia to heat and mechanical stimulation. Correspondingly, it excites nociceptors in various tissues and sensitizes them to heat, whereas sensitizing effect on the mechanical response of nociceptors is not well established. Protein kinase C and TRPV1 contribute to the sensitizing mechanism of bradykinin to heat. In addition, TRPA1 and other ion channels appear to contribute to excitation caused by bradykinin. Finally, prostaglandins sensitize bradykinin-induced excitation in normal tissues by restoring desensitized responses due to the inhibition of protein kinase A.
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