Mechanically induced axon reflex and hyperalgesia in human UV-B burn are reduced by systemic lidocaine
W Koppert, V Brueckl, C Weidner, M Schmelz - European journal of pain, 2004 - Elsevier
The mechanisms for the induction of primary mechanical hyperalgesia are unclear. We
analyzed the neurogenic axon reflex erythema (flare) following phasic mechanical
stimulation in normal and in UV-B irradiated skin. In a cross-over double blind design (n=
10), low dose of systemic lidocaine suppressed mechanical hyperalgesia in sunburned skin
and in the mechanically induced flare. Phasic mechanical stimulation, even at painful
intensities, did not evoke a flare reaction in normal skin. However, stimulation within the UV …
analyzed the neurogenic axon reflex erythema (flare) following phasic mechanical
stimulation in normal and in UV-B irradiated skin. In a cross-over double blind design (n=
10), low dose of systemic lidocaine suppressed mechanical hyperalgesia in sunburned skin
and in the mechanically induced flare. Phasic mechanical stimulation, even at painful
intensities, did not evoke a flare reaction in normal skin. However, stimulation within the UV …