Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and …
O Obreja, M Ringkamp, B Namer, E Forsch, A Klusch… - Pain, 2010 - Elsevier
Activity-dependent slowing of conduction velocity (ADS) differs between classes of human
nociceptors. These differences likely reflect particular expression and use-dependent slow
inactivation of axonal ion channels and other mechanisms governing axonal excitability. In
this study, we compared ADS of porcine and human cutaneous C-fibers. Extracellular
recordings were performed from peripheral nerves, using teased fiber technique in pigs and
microneurography in humans. We assessed electrically-induced conduction changes and …
nociceptors. These differences likely reflect particular expression and use-dependent slow
inactivation of axonal ion channels and other mechanisms governing axonal excitability. In
this study, we compared ADS of porcine and human cutaneous C-fibers. Extracellular
recordings were performed from peripheral nerves, using teased fiber technique in pigs and
microneurography in humans. We assessed electrically-induced conduction changes and …