Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice
Z Helyes, Á Szabó, K Sándor, K Elekes, J Németh… - Pain, 2005 - Elsevier
Capsaicin-sensitive, TRPV1 (transient receptor potential vanilloid 1) receptor-expressing
primary sensory neurons exert local and systemic efferent effects besides the classical
afferent function. The TRPV1 receptor is considered a molecular integrator of various
physico-chemical noxious stimuli. In the present study its role was analysed in acute
nociceptive tests and chronic neuropathy models by comparison of wild-type (WT) and
TRPV1 knockout (KO) mice. The formalin-induced acute nocifensive behaviour …
primary sensory neurons exert local and systemic efferent effects besides the classical
afferent function. The TRPV1 receptor is considered a molecular integrator of various
physico-chemical noxious stimuli. In the present study its role was analysed in acute
nociceptive tests and chronic neuropathy models by comparison of wild-type (WT) and
TRPV1 knockout (KO) mice. The formalin-induced acute nocifensive behaviour …