Pain-associated signals, acidosis and lysophosphatidic acid, modulate the neuronal K2P2. 1 channel
A Cohen, R Sagron, E Somech, Y Segal-Hayoun… - Molecular and Cellular …, 2009 - Elsevier
Pain is a physiological state promoting protective responses to harmful episodes. However,
pain can become pathophysiological and become a chronic disruptive condition, damaging
quality of life. The mammalian K2P2. 1 (KCNK2, TREK-1) channel, expressed in sensory
neurons of the dorsal root ganglia, was previously identified as a polymodal molecular
sensor involved in pain perception. Here, we report that two pain-associated signals,
external acidosis and lysophosphatidic acid (LPA), known to rise during injury, inflammation …
pain can become pathophysiological and become a chronic disruptive condition, damaging
quality of life. The mammalian K2P2. 1 (KCNK2, TREK-1) channel, expressed in sensory
neurons of the dorsal root ganglia, was previously identified as a polymodal molecular
sensor involved in pain perception. Here, we report that two pain-associated signals,
external acidosis and lysophosphatidic acid (LPA), known to rise during injury, inflammation …