[HTML][HTML] TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat
JJ Lawson, SL McIlwrath, CJ Woodbury, BM Davis… - The journal of pain, 2008 - Elsevier
In the present study, a murine ex vivo somatosensory system preparation was used to
determine the response characteristics of cutaneous sensory neurons staining positively for
TRPV1 or TRPV2. TRPV1 immunostaining was found exclusively (11/11) in a specific set of
mechanically insensitive unmyelinated (C) nociceptors that responded to heating of their
receptive fields. No cutaneous C-fibers that responded to both mechanical and heat stimuli
stained positively for TRPV1 (0/62). The relationship between TRPV2 and heat transduction …
determine the response characteristics of cutaneous sensory neurons staining positively for
TRPV1 or TRPV2. TRPV1 immunostaining was found exclusively (11/11) in a specific set of
mechanically insensitive unmyelinated (C) nociceptors that responded to heating of their
receptive fields. No cutaneous C-fibers that responded to both mechanical and heat stimuli
stained positively for TRPV1 (0/62). The relationship between TRPV2 and heat transduction …