[HTML][HTML] The Na, K-ATPase α2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice
AE Moseley, SP Lieske, RK Wetzel, PF James… - Journal of Biological …, 2003 - ASBMB
Na, K-ATPase is an ion transporter that impacts neural and glial physiology by direct
electrogenic activity and the modulation of ion gradients. Its three isoforms in brain have cell-
type and development-specific expression patterns. Interestingly, our studies demonstrate
that in late gestation, the α2 isoform is widely expressed in neurons, unlike in the adult brain,
in which α2 has been shown to be expressed primarily in astrocytes. This unexpected
distribution of α2 isoform expression in neurons is interesting in light of our examination of …
electrogenic activity and the modulation of ion gradients. Its three isoforms in brain have cell-
type and development-specific expression patterns. Interestingly, our studies demonstrate
that in late gestation, the α2 isoform is widely expressed in neurons, unlike in the adult brain,
in which α2 has been shown to be expressed primarily in astrocytes. This unexpected
distribution of α2 isoform expression in neurons is interesting in light of our examination of …