Understanding the role of voltage-gated sodium channels in nociception may provide
important insights into pain mechanisms. Voltage-gated sodium channels are critically
important for electrogenesis and nerve impulse conduction, and a target for important
clinically relevant analgesics such as lidocaine. Furthermore, within the last decade studies
have shown that certain sodium channel isoforms are predominantly expressed in
peripheral sensory neurons associated with pain sensation, and that the expression and …