Injection of nerve growth factor into human masseter muscle evokes long-lasting mechanical allodynia and hyperalgesia
P Svensson, BE Cairns, K Wang, L Arendt-Nielsen - Pain, 2003 - Elsevier
Nerve growth factor (NGF) is a neurotrophic protein with a pivotal role in development and
maintenance of the nervous system on one side and inflammatory and neuropathic pain
states on the other. NGF causes clear signs of behavioral hyperalgesia in animal models
and following intradermal and systemic administration in humans. The present double-
blinded, placebo-controlled study was designed to test quantitatively the effect and duration
(1h, 1, 7, 14, 21 and 28 days) of NGF (5μg in 0.2 ml) injected into the masseter muscle …
maintenance of the nervous system on one side and inflammatory and neuropathic pain
states on the other. NGF causes clear signs of behavioral hyperalgesia in animal models
and following intradermal and systemic administration in humans. The present double-
blinded, placebo-controlled study was designed to test quantitatively the effect and duration
(1h, 1, 7, 14, 21 and 28 days) of NGF (5μg in 0.2 ml) injected into the masseter muscle …