Differential effect of ketamine and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury pain
H Gottrup, FW Bach, G Juhl… - The Journal of the …, 2006 - pubs.asahq.org
Background The mechanisms underlying neuropathic pain are incompletely understood.
Targeting specific molecular mechanisms in the pain signaling system may assist in
understanding key features in neuropathic pains such as allodynia. This study examined the
effect of systemically administered ketamine, an N-methyl-D-aspartate receptor antagonist
and lidocaine, a sodium channel blocker, on spontaneous pain, brush-evoked pain, and
pinprick-evoked pain in patients with nerve injury pain. Methods Twenty patients participated …
Targeting specific molecular mechanisms in the pain signaling system may assist in
understanding key features in neuropathic pains such as allodynia. This study examined the
effect of systemically administered ketamine, an N-methyl-D-aspartate receptor antagonist
and lidocaine, a sodium channel blocker, on spontaneous pain, brush-evoked pain, and
pinprick-evoked pain in patients with nerve injury pain. Methods Twenty patients participated …