[HTML][HTML] Laminin-1 promotes angiogenesis in synergy with fibroblast growth factor by distinct regulation of the gene and protein expression profile in endothelial cells
J Dixelius, L Jakobsson, E Genersch, S Bohman… - Journal of Biological …, 2004 - ASBMB
Laminins are widely distributed extracellular matrix proteins. Certain laminin isoforms are
predominant in vascular basement membranes and may be critical in maintaining the
stability of the mature vessel. On the other hand, formation of new vessels during
angiogenesis requires degradation of the basement membrane, exposing the endothelial
cells to other laminin isoforms in the surrounding extracellular matrix. We studied the effects
of laminin-1 (LN-1) in different in vitro and in vivo models for angiogenesis. LN-1 induced …
predominant in vascular basement membranes and may be critical in maintaining the
stability of the mature vessel. On the other hand, formation of new vessels during
angiogenesis requires degradation of the basement membrane, exposing the endothelial
cells to other laminin isoforms in the surrounding extracellular matrix. We studied the effects
of laminin-1 (LN-1) in different in vitro and in vivo models for angiogenesis. LN-1 induced …