The nuclear regulator LaeA has been shown to govern production of multiple secondary
metabolites in Aspergillus nidulans and Aspergillus fumigatus. Herein we examine the role
of this protein in Aspergillus flavus. Similarly as in other Aspergilli, LaeA had a major effect
on A. flavus secondary metabolism where ΔlaeA and over-expression laeA (OE:: laeA)
strains yielded opposite phenotypes resulting in decreased (increased) secondary
metabolite production. The two mutant strains also exhibited striking morphological …