Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor …
The 92-kDa type IV collagenase (92-kDa gelatinase B also referred to as MMP-9), which
plays a critical role in extracellular matrix degradation, is regulated by growth factors that
mediate their effects through the ras proto-oncogene. The current study was undertaken to
determine the transcriptional requirements for the induction of 92-kDa gelatinase B
expression by an activated ras oncogene. Transfection of OVCAR-3 cells with an expression
vector encoding an activated Ha-ras increased 92-kDa gelatinolytic activity and stimulated …
plays a critical role in extracellular matrix degradation, is regulated by growth factors that
mediate their effects through the ras proto-oncogene. The current study was undertaken to
determine the transcriptional requirements for the induction of 92-kDa gelatinase B
expression by an activated ras oncogene. Transfection of OVCAR-3 cells with an expression
vector encoding an activated Ha-ras increased 92-kDa gelatinolytic activity and stimulated …
