Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase
C Birchmeier, E Gherardi - Trends in cell biology, 1998 - cell.com
C Birchmeier, E Gherardi
Trends in cell biology, 1998•cell.comA number of developmental processes that involve cell migration, growth or morphogenesis
depend on extracellular signals. A molecule that provides such signals, known as
hepatocyte growth factor/scatter factor (HGF/SF), has attracted considerable interest in
recent years because of its distinct structure, mechanism of activation and important roles
throughout embryogenesis. This review discusses the main features of HGF/SF and its
receptor, the product of the c-met protooncogene, and their role in embryogenesis.
depend on extracellular signals. A molecule that provides such signals, known as
hepatocyte growth factor/scatter factor (HGF/SF), has attracted considerable interest in
recent years because of its distinct structure, mechanism of activation and important roles
throughout embryogenesis. This review discusses the main features of HGF/SF and its
receptor, the product of the c-met protooncogene, and their role in embryogenesis.
Abstract
A number of developmental processes that involve cell migration, growth or morphogenesis depend on extracellular signals. A molecule that provides such signals, known as hepatocyte growth factor/scatter factor (HGF/SF), has attracted considerable interest in recent years because of its distinct structure, mechanism of activation and important roles throughout embryogenesis. This review discusses the main features of HGF/SF and its receptor, the product of the c-met protooncogene, and their role in embryogenesis.
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