Comparative genomic instabilities of thyroid and colon cancers

DL Stoler, NJ Nowak, S Matsui… - … –Head & Neck …, 2007 - jamanetwork.com
Objectives To assess the forms and extent of genomic instability in thyroid cancers and
colorectal neoplasms and to determine if such measurements could explain the generally
excellent prognosis of thyroid malignant neoplasms compared with colon carcinoma. Design
Tumor genome analyses. Genomic instability was measured by the following 4 methods,
listed in ascending order based on the size of events detected: inter–simple sequence
repeat polymerase chain reaction (ISSR-PCR), fractional allelic loss (FAL) analysis, array …