The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
L Korhonen, D Lindholm - The Journal of cell biology, 2004 - rupress.org
The Journal of cell biology, 2004•rupress.org
The ubiquitin proteasome system (UPS) contributes to the pathophysiology of
neurodegenerative diseases, and it is also a major determinant of synaptic protein
degradation and activity. Recent studies in rodents and in the fruit fly Drosophila have
shown that the activity of the UPS is involved in axonal degeneration. Increased knowledge
of the UPS in synaptic and axonal reactions may provide novel drug targets for treatments of
neuronal injuries and neurodegenerative disorders.
neurodegenerative diseases, and it is also a major determinant of synaptic protein
degradation and activity. Recent studies in rodents and in the fruit fly Drosophila have
shown that the activity of the UPS is involved in axonal degeneration. Increased knowledge
of the UPS in synaptic and axonal reactions may provide novel drug targets for treatments of
neuronal injuries and neurodegenerative disorders.
The ubiquitin proteasome system (UPS) contributes to the pathophysiology of neurodegenerative diseases, and it is also a major determinant of synaptic protein degradation and activity. Recent studies in rodents and in the fruit fly Drosophila have shown that the activity of the UPS is involved in axonal degeneration. Increased knowledge of the UPS in synaptic and axonal reactions may provide novel drug targets for treatments of neuronal injuries and neurodegenerative disorders.
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