SOX2 amplification is a common event in squamous cell carcinomas of different organ sites
S Maier, T Wilbertz, M Braun, V Scheble, M Reischl… - Human pathology, 2011 - Elsevier
Acquired chromosomal aberrations, including gene copy number alterations, are involved in
the development and progression of human malignancies. SOX2, a transcription factor–
coding gene located at 3q26. 33, is known to be recurrently and specifically amplified in
squamous cell carcinomas of the lung, the esophagus, and the oral cavity. In these organs,
the SOX2 protein plays an important role in tumorigenesis and tumor survival. The aim of
this study was to determine whether SOX2 amplification is also found in squamous cell …
the development and progression of human malignancies. SOX2, a transcription factor–
coding gene located at 3q26. 33, is known to be recurrently and specifically amplified in
squamous cell carcinomas of the lung, the esophagus, and the oral cavity. In these organs,
the SOX2 protein plays an important role in tumorigenesis and tumor survival. The aim of
this study was to determine whether SOX2 amplification is also found in squamous cell …
