Real-time imaging of heterotypic platelet-neutrophil interactions on the activated endothelium during vascular inflammation and thrombus formation in live mice
Interaction of activated platelets and leukocytes (mainly neutrophils) on the activated
endothelium mediates thrombosis and vascular inflammation. 1, 2 During thrombus
formation at the site of arteriolar injury, platelets adherent to the activated endothelium and
subendothelial matrix proteins support neutrophil rolling and adhesion. 3 Conversely, under
venular inflammatory conditions, neutrophils adherent to the activated endothelium can
support adhesion and accumulation of circulating platelets. Heterotypic platelet-neutrophil …
endothelium mediates thrombosis and vascular inflammation. 1, 2 During thrombus
formation at the site of arteriolar injury, platelets adherent to the activated endothelium and
subendothelial matrix proteins support neutrophil rolling and adhesion. 3 Conversely, under
venular inflammatory conditions, neutrophils adherent to the activated endothelium can
support adhesion and accumulation of circulating platelets. Heterotypic platelet-neutrophil …