[HTML][HTML] Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 …
K Piechotta, J Lu, E Delpire - Journal of Biological Chemistry, 2002 - ASBMB
Cells respond to stress stimuli by mounting specific responses. During osmotic and oxidative
stress, cation chloride cotransporters, eg Na-K-2Cl and K-Cl cotransporters, are activated to
maintain fluid/ion homeostasis. Here we report the interaction of the stress-related serine-
threonine kinases Ste20-relatedproline-alanine-rich kinase (SPAK) and oxidative stress
response 1 (OSR1) with the cotransporters KCC3, NKCC1, and NKCC2 but not KCC1 and
KCC4. The interaction was identified using yeast two-hybrid assays and confirmed via …
stress, cation chloride cotransporters, eg Na-K-2Cl and K-Cl cotransporters, are activated to
maintain fluid/ion homeostasis. Here we report the interaction of the stress-related serine-
threonine kinases Ste20-relatedproline-alanine-rich kinase (SPAK) and oxidative stress
response 1 (OSR1) with the cotransporters KCC3, NKCC1, and NKCC2 but not KCC1 and
KCC4. The interaction was identified using yeast two-hybrid assays and confirmed via …