High-frequency audiometric monitoring for early detection of aminoglycoside ototoxicity
SA Fausti, JA Henry, HI Schaffer… - Journal of Infectious …, 1992 - academic.oup.com
SA Fausti, JA Henry, HI Schaffer, DJ Olson, RH Frey, WJ McDonald
Journal of Infectious Diseases, 1992•academic.oup.comAbstract Treatment with aminoglycosidesis known to cause irreversible hearing loss,
typically affecting higher-frequency hearing first and progressing to lower frequencies.
Standardized methodology has not been developed for early detection of ototoxicity. Serial
conventional (0.25–8 kHz) and high-frequency (9–20 kHz) hearing threshold monitoring was
done prospectivelyin 53 hospitalized patients administered aminoglycosides. Hearing loss
occurred in 47% of the ears studied, with hearing loss first appearing in the high-frequency …
typically affecting higher-frequency hearing first and progressing to lower frequencies.
Standardized methodology has not been developed for early detection of ototoxicity. Serial
conventional (0.25–8 kHz) and high-frequency (9–20 kHz) hearing threshold monitoring was
done prospectivelyin 53 hospitalized patients administered aminoglycosides. Hearing loss
occurred in 47% of the ears studied, with hearing loss first appearing in the high-frequency …
Abstract
Treatment with aminoglycosidesis known to cause irreversible hearing loss, typically affecting higher-frequency hearing first and progressing to lower frequencies. Standardized methodology has not been developed for early detection of ototoxicity. Serial conventional (0.25–8 kHz) and high-frequency (9–20 kHz) hearing threshold monitoring was done prospectivelyin 53 hospitalized patients administered aminoglycosides. Hearing loss occurred in 47% of the ears studied, with hearing loss first appearing in the high-frequency range in 71% of ears showing change. Analysis of data on an individual basis revealed a five-frequency range most susceptible to initial ototoxicity. Testing only this range would have resulted in early identification of 82% of ears showing change. Results confirm the critical need for serial auditory threshold monitoring encompassing high frequencies in patients receiving aminoglycosides.A shortened five-frequency monitoring protocol is presented and suggested for use with patients unable to tolerate lengthy audiometric testing procedures.
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