[HTML][HTML] GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy
I Scott, BR Webster, CK Chan, JU Okonkwo… - Journal of Biological …, 2014 - ASBMB
Cellular mitochondrial content is governed by the competing processes of organelle
biogenesis and degradation. It is proposed that these programs are tightly regulated to
ensure that the cell maintains sufficient organelles to meet its biosynthetic, energetic, and
other homeostatic requirements. We recently reported that GCN5L1, a putative nutrient-
sensing regulator, controls mitochondrial removal by autophagy. Here we show that genetic
deletion of GCN5L1 has a direct positive effect on the expression and activity of …
biogenesis and degradation. It is proposed that these programs are tightly regulated to
ensure that the cell maintains sufficient organelles to meet its biosynthetic, energetic, and
other homeostatic requirements. We recently reported that GCN5L1, a putative nutrient-
sensing regulator, controls mitochondrial removal by autophagy. Here we show that genetic
deletion of GCN5L1 has a direct positive effect on the expression and activity of …