Ultrasound modulates the splenic neuroimmune axis in attenuating AKI

JC Gigliotti, L Huang, A Bajwa, H Ye… - Journal of the …, 2015 - journals.lww.com
We showed previously that prior exposure to a modified ultrasound regimen prevents kidney
ischemia-reperfusion injury (IRI) likely via the splenic cholinergic anti-inflammatory pathway
(CAP) and α7 nicotinic acetylcholine receptors (α7nAChR). However, it is unclear how
ultrasound stimulates the splenic CAP. Further investigating the role of the spleen in
ischemic injury, we found that prior splenectomy (–7d) or chemical sympathectomy of the
spleen with 6-hydroxydopamine (6OHDA;–14d) exacerbated injury after subthreshold (24 …