An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer
O Maertens, K Cichowski - Advances in biological regulation, 2014 - Elsevier
The RAS pathway is one of the most commonly deregulated pathways in human cancer.
Mutations in RAS genes occur in nearly 30% of all human tumors. However in some tumor
types RAS mutations are conspicuously absent or rare, despite the fact that RAS and
downstream effector pathways are hyperactivated. Recently, RAS GTPase Activating
Proteins (RAS GAPs) have emerged as an expanding class of tumor suppressors that, when
inactivated, provide an alternative mechanism of activating RAS. RAS GAPs normally turn off …
Mutations in RAS genes occur in nearly 30% of all human tumors. However in some tumor
types RAS mutations are conspicuously absent or rare, despite the fact that RAS and
downstream effector pathways are hyperactivated. Recently, RAS GTPase Activating
Proteins (RAS GAPs) have emerged as an expanding class of tumor suppressors that, when
inactivated, provide an alternative mechanism of activating RAS. RAS GAPs normally turn off …
