Reversal of glomerulosclerosis after high-dose enalapril treatment in subtotally nephrectomized rats

M Adamczak, ML Gross, J Krtil, A Koch… - Journal of the …, 2003 - journals.lww.com
Interventions to block the renin-angiotensin system (RAS) halt the progression of renal
lesions in renal damage models. It has recently also been reported that established
glomerulosclerosis can be reversed by pharmacologic blockade of the RAS. It was the aim
of this study to confirm that high doses of angiotensin-converting enzyme (ACE) inhibitors
reverse established glomerulosclerosis and to extend the findings by providing quantitative
information on glomerular geometry, podocytes and other glomerular cells, renal vessels …