[HTML][HTML] Metabolic diapause in pancreatic β-cells expressing a gain-of-function mutant of the forkhead protein Foxo1
J Buteau, A Shlien, S Foisy, D Accili - Journal of Biological Chemistry, 2007 - ASBMB
Diabetes is associated with decreased pancreatic β-cell function and mass. It is unclear
whether diabetes treatment should aim at restoring β-cell performance/mass or at inducing"
β-cell rest" to prevent further deterioration. The transcription factor Foxo1 protects β-cells
against oxidative stress induced by hyperglycemia and prevents β-cell replication in insulin-
resistant states. Here we show that these combined effects are associated with a concerted
repression of genes involved in glycolysis, nitric-oxide synthesis, G protein-coupled receptor …
whether diabetes treatment should aim at restoring β-cell performance/mass or at inducing"
β-cell rest" to prevent further deterioration. The transcription factor Foxo1 protects β-cells
against oxidative stress induced by hyperglycemia and prevents β-cell replication in insulin-
resistant states. Here we show that these combined effects are associated with a concerted
repression of genes involved in glycolysis, nitric-oxide synthesis, G protein-coupled receptor …