Is age-related macular degeneration a microvascular disease?

RF Mullins, A Khanna, DP Schoo, BA Tucker… - Retinal Degenerative …, 2014 - Springer
Retinal Degenerative Diseases: Mechanisms and Experimental Therapy, 2014Springer
Age-related macular degeneration (AMD) is a common, degenerative disease of the central
retina affecting millions of elderly in the USA alone and many more worldwide. A better
understanding of the pathophysiology of AMD will be essential for developing new
treatments. In this review, we discuss the potential impact of complement complex
deposition at the choriocapillaris of aging eyes and the relationship between choriocapillaris
loss and drusen formation. We further propose a model that integrates genetic and …
Abstract
Age-related macular degeneration (AMD) is a common, degenerative disease of the central retina affecting millions of elderly in the USA alone and many more worldwide. A better understanding of the pathophysiology of AMD will be essential for developing new treatments. In this review, we discuss the potential impact of complement complex deposition at the choriocapillaris of aging eyes and the relationship between choriocapillaris loss and drusen formation. We further propose a model that integrates genetic and anatomical findings in AMD and suggest the implications of these findings for future therapies.
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