Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
Insulin-expressing cells that have been differentiated from human pluripotent stem cells in
vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell
maturation in mice was studied to find genetic markers that enable screens for factors that
induce bona fide beta cells in vitro. We find that functional beta-cell maturation is marked by
an increase in the glucose threshold for insulin secretion and by expression of the gene
urocortin 3.
vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell
maturation in mice was studied to find genetic markers that enable screens for factors that
induce bona fide beta cells in vitro. We find that functional beta-cell maturation is marked by
an increase in the glucose threshold for insulin secretion and by expression of the gene
urocortin 3.
Abstract
Insulin-expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic markers that enable screens for factors that induce bona fide beta cells in vitro. We find that functional beta-cell maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of the gene urocortin 3.
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