[HTML][HTML] Peroxisome proliferator-activated receptor γ activation promotes infiltration of alternatively activated macrophages into adipose tissue

R Stienstra, C Duval, S Keshtkar, J van der Laak… - Journal of Biological …, 2008 - ASBMB
Obesity is associated with infiltration of macrophages into adipose tissue. Adipose
macrophages may contribute to an elevated inflammatory status by secreting a variety of
proinflammatory mediators, including tumor necrosis factor α and interleukin-6 (IL-6). Recent
data suggest that during diet-induced obesity the phenotype of adipose-resident
macrophages changes from alternatively activated macrophages toward a more classical
and pro-inflammatory phenotype. Here, we explore the effect of peroxisome proliferator …