[HTML][HTML] Open chromatin profiling in mice livers reveals unique chromatin variations induced by high fat diet

A Leung, BW Parks, J Du, C Trac, R Setten… - Journal of Biological …, 2014 - ASBMB
Metabolic diseases result from multiple genetic and environmental factors. We report here
that one manner in which environmental factors can contribute to metabolic disease
progression is through modification to chromatin. We demonstrate that high fat diet leads to
chromatin remodeling in the livers of C57BL/6J mice, as compared with mice fed a control
diet, and that these chromatin changes are associated with changes in gene expression. We
further show that the regions of greatest variation in chromatin accessibility are targeted by …