Transforming growth factor-β in T-cell biology

L Gorelik, RA Flavell - Nature Reviews Immunology, 2002 - nature.com
L Gorelik, RA Flavell
Nature Reviews Immunology, 2002nature.com
Strict control of T-cell homeostasis is required to permit normal immune responses and
prevent undesirable self-targeted responses. Transforming growth factor-β (TGF-β) has
been shown to have an essential role in that regulation. Owing to its broad expression, and
inhibitory effects on multiple cell types of the immune system, TGF-β regulation is complex.
Through advances in cell-specific targeting of TGF-β signalling in vivo, the role of TGF-β in T-
cell regulation has become clearer. Recent in vitro studies provide a better understanding of …
Abstract
Strict control of T-cell homeostasis is required to permit normal immune responses and prevent undesirable self-targeted responses. Transforming growth factor-β (TGF-β) has been shown to have an essential role in that regulation. Owing to its broad expression, and inhibitory effects on multiple cell types of the immune system, TGF-β regulation is complex. Through advances in cell-specific targeting of TGF-β signalling in vivo, the role of TGF-β in T-cell regulation has become clearer. Recent in vitrostudies provide a better understanding of how TGF-β regulates T-cell homeostasis, through multiple mechanisms involving numerous cell types.
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