Local synthesis of complement component C3 regulates acute renal transplant rejection

JR Pratt, SA Basheer, SH Sacks - Nature medicine, 2002 - nature.com
JR Pratt, SA Basheer, SH Sacks
Nature medicine, 2002nature.com
Accumulating evidence suggests that innate immunity interacts with the adaptive immune
system to identify potentially harmful antigens and eliminate them from the host. A central
facet of innate immunity is complement, which for some time has been recognized as a
contributor to inflammation in transplant rejection but without detailed analysis of its role in
what is principally a T cell–mediated process. Moreover, epithelial and vascular tissues at
local sites of inflammation secrete complement components; however, the role of such local …
Abstract
Accumulating evidence suggests that innate immunity interacts with the adaptive immune system to identify potentially harmful antigens and eliminate them from the host. A central facet of innate immunity is complement, which for some time has been recognized as a contributor to inflammation in transplant rejection but without detailed analysis of its role in what is principally a T cell–mediated process. Moreover, epithelial and vascular tissues at local sites of inflammation secrete complement components; however, the role of such local synthesis remains unclear. Here we show that the absence of locally synthesized complement component C3 is capable of modulating the rejection of renal allografts in vivo and regulating T-cell responses in vivo and in vitro. The results indicate that improved success in kidney transplantation could come from therapeutic manipulation of innate immunity in concert with T cell–directed immunosuppression.
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