[HTML][HTML] Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by …
S Shah, EM King, A Chandrasekhar… - Journal of Biological …, 2014 - ASBMB
Glucocorticoids act on the glucocorticoid receptor (NR3C1) to repress inflammatory gene
expression. This is central to their anti-inflammatory effectiveness and rational improvements
in therapeutic index depend on understanding the mechanism. Human pulmonary epithelial
A549 cells were used to study the role of the mitogen-activated protein kinase (MAPK)
phosphatase, dual-specificity phosphatase 1 (DUSP1), in the dexamethasone repression of
11 inflammatory genes induced, in a MAPK-dependent manner, by interleukin-1β (IL1B) …
expression. This is central to their anti-inflammatory effectiveness and rational improvements
in therapeutic index depend on understanding the mechanism. Human pulmonary epithelial
A549 cells were used to study the role of the mitogen-activated protein kinase (MAPK)
phosphatase, dual-specificity phosphatase 1 (DUSP1), in the dexamethasone repression of
11 inflammatory genes induced, in a MAPK-dependent manner, by interleukin-1β (IL1B) …