Glucocorticoids downregulate the vasopressin-regulated urea transporter in rat terminal inner medullary collecting ducts.

M Naruse, JD Klein, ZM Ashkar… - Journal of the …, 1997 - journals.lww.com
This study tested whether glucocorticoids regulate tubular urea transport. Urea permeability
was measured in perfused inner medullary collecting duct (IMCD) subsegments from rats
that underwent adrenalectomy, adrenalectomy plus replacement with a physiologic dose of
glucocorticoid (dexamethasone), or sham operation. Compared with sham rats, basal urea
permeability in terminal IMCD was significantly increased in adrenalectomized rats and
reduced in dexamethasone-treated rats. Vasopressin significantly increased urea …