[PDF][PDF] CaV1. 2 rather than CaV1. 3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells
MD Nitert, CLF Nagorny, A Wendt… - Journal of molecular …, 2008 - scholar.archive.org
MD Nitert, CLF Nagorny, A Wendt, L Eliasson, H Mulder
Journal of molecular endocrinology, 2008•scholar.archive.orgIn clonal b-cell lines and islets from different species, a variety of calcium channels are
coupled to glucose-stimulated insulin secretion. The aim of this study was to identify the
voltage-gated calcium channels that control insulin secretion in insulinoma (INS)-1 832/13
cells. The mRNA level of CaV1. 2 exceeded that of CaV1. 3 and CaV2. 3 two-fold. Insulin
secretion, which rose tenfold in response to 16. 7 mM glucose, was completely abolished by
5 mM isradipine that blocks
coupled to glucose-stimulated insulin secretion. The aim of this study was to identify the
voltage-gated calcium channels that control insulin secretion in insulinoma (INS)-1 832/13
cells. The mRNA level of CaV1. 2 exceeded that of CaV1. 3 and CaV2. 3 two-fold. Insulin
secretion, which rose tenfold in response to 16. 7 mM glucose, was completely abolished by
5 mM isradipine that blocks
Abstract
In clonal b-cell lines and islets from different species, a variety of calcium channels are coupled to glucose-stimulated insulin secretion. The aim of this study was to identify the voltage-gated calcium channels that control insulin secretion in insulinoma (INS)-1 832/13 cells. The mRNA level of CaV1. 2 exceeded that of CaV1. 3 and CaV2. 3 two-fold. Insulin secretion, which rose tenfold in response to 16. 7 mM glucose, was completely abolished by 5 mM isradipine that blocks
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