[HTML][HTML] Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin
Defective membrane repair can contribute to the progression of muscular dystrophy.
Although mutations in caveolin-3 (Cav3) and dysferlin are linked to muscular dystrophy in
human patients, the molecular mechanism underlying the functional interplay between Cav3
and dysferlin in membrane repair of muscle physiology and disease has not been fully
resolved. We recently discovered that mitsugumin 53 (MG53), a muscle-specific TRIM (Tri-
partite motif) family protein (TRIM72), contributes to intracellular vesicle trafficking and is an …
Although mutations in caveolin-3 (Cav3) and dysferlin are linked to muscular dystrophy in
human patients, the molecular mechanism underlying the functional interplay between Cav3
and dysferlin in membrane repair of muscle physiology and disease has not been fully
resolved. We recently discovered that mitsugumin 53 (MG53), a muscle-specific TRIM (Tri-
partite motif) family protein (TRIM72), contributes to intracellular vesicle trafficking and is an …