Regulation of JAK–STAT signalling in the immune system
K Shuai, B Liu - Nature Reviews Immunology, 2003 - nature.com
K Shuai, B Liu
Nature Reviews Immunology, 2003•nature.comThe cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) pathway has an important role in the control of immune responses. Dysregulation of
JAK–STAT signalling is associated with various immune disorders. The signalling strength,
kinetics and specificity of the JAK–STAT pathway are modulated at many levels by distinct
regulatory proteins. Here, we review recent studies on the regulation of the JAK–STAT
pathway that will enhance our ability to design rational therapeutic strategies for immune …
(STAT) pathway has an important role in the control of immune responses. Dysregulation of
JAK–STAT signalling is associated with various immune disorders. The signalling strength,
kinetics and specificity of the JAK–STAT pathway are modulated at many levels by distinct
regulatory proteins. Here, we review recent studies on the regulation of the JAK–STAT
pathway that will enhance our ability to design rational therapeutic strategies for immune …
Abstract
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway has an important role in the control of immune responses. Dysregulation of JAK–STAT signalling is associated with various immune disorders. The signalling strength, kinetics and specificity of the JAK–STAT pathway are modulated at many levels by distinct regulatory proteins. Here, we review recent studies on the regulation of the JAK–STAT pathway that will enhance our ability to design rational therapeutic strategies for immune diseases.
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