[HTML][HTML] Donor-specific antibodies are produced locally in ectopic lymphoid structures in cardiac allografts
MMH Huibers, AJ Gareau, JMT Beerthuijzen… - American Journal of …, 2017 - Elsevier
Cardiac allograft vasculopathy (CAV) is a transplant pathology, limiting graft survival after
heart transplantation. CAV arteries are surrounded by ectopic lymphoid structures (ELS)
containing B cells and plasma cells. The aim of this study was to characterize the antigenic
targets of antibodies produced in ELS. Coronary arteries and surrounding epicardial tissue
from 56 transplant recipients were collected during autopsy. Immunofluorescence was used
to identify antibody-producing plasma cells. Immunoglobulin levels in tissue lysates were …
heart transplantation. CAV arteries are surrounded by ectopic lymphoid structures (ELS)
containing B cells and plasma cells. The aim of this study was to characterize the antigenic
targets of antibodies produced in ELS. Coronary arteries and surrounding epicardial tissue
from 56 transplant recipients were collected during autopsy. Immunofluorescence was used
to identify antibody-producing plasma cells. Immunoglobulin levels in tissue lysates were …