Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survival
G Vlad, EK Ho, ER Vasilescu, AI Colovai, MB Stokes… - Human immunology, 2009 - Elsevier
Presensitizing alloantibodies may represent a grave danger in organ transplantation,
increasing the risk of antibody-mediated rejection (AMR) and graft loss. However, not all
antibodies are harmful to the graft. In our study of a cohort of 325 deceased-donor renal
allograft recipients, the patients were determined eligible to receive an allograft based on a
negative complement-dependent cytotoxicity (CDC) crossmatch (XM). Yet at the time of
transplantation, many candidates displayed donor-specific antibodies (DSA) by more …
increasing the risk of antibody-mediated rejection (AMR) and graft loss. However, not all
antibodies are harmful to the graft. In our study of a cohort of 325 deceased-donor renal
allograft recipients, the patients were determined eligible to receive an allograft based on a
negative complement-dependent cytotoxicity (CDC) crossmatch (XM). Yet at the time of
transplantation, many candidates displayed donor-specific antibodies (DSA) by more …