Pathologic findings in lung allografts with anti-HLA antibodies
MM DeNicola, SS Weigt, JA Belperio, EF Reed… - The Journal of Heart and …, 2013 - Elsevier
BACKGROUND: Despite data indicating a positive correlation between donor-specific anti-
HLA antibodies (DSAs) and early development of bronchiolitis obliterans syndrome (BOS) in
lung allografts, the role of an antibody-mediated process in acute and chronic lung allograft
rejection has not been elucidated. In this study we evaluated pathologic features of
transplant lung biopsies in patients with and without DSAs. METHODS: Forty-one lung
transplant biopsies from 41 patients at our institution were included in our study. The biopsy …
HLA antibodies (DSAs) and early development of bronchiolitis obliterans syndrome (BOS) in
lung allografts, the role of an antibody-mediated process in acute and chronic lung allograft
rejection has not been elucidated. In this study we evaluated pathologic features of
transplant lung biopsies in patients with and without DSAs. METHODS: Forty-one lung
transplant biopsies from 41 patients at our institution were included in our study. The biopsy …