Chemical target and pathway toxicity mechanisms defined in primary human cell systems
EL Berg, J Yang, J Melrose, D Nguyen, S Privat… - … of pharmacological and …, 2010 - Elsevier
INTRODUCTION: The ability to predict the health effects resulting from drug or chemical
exposure has been challenging due to the complexity of human biology. Approaches that
detect and discriminate a broad range of mechanisms in testing formats that are predictive
and yet cost-effective are needed. METHODS: Here, we evaluated the performance of
BioMAP systems, primary human cell-based disease models, as a platform for
characterization of chemical toxicity mechanisms. For this we tested a set of compounds with …
exposure has been challenging due to the complexity of human biology. Approaches that
detect and discriminate a broad range of mechanisms in testing formats that are predictive
and yet cost-effective are needed. METHODS: Here, we evaluated the performance of
BioMAP systems, primary human cell-based disease models, as a platform for
characterization of chemical toxicity mechanisms. For this we tested a set of compounds with …