[HTML][HTML] Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥ C20)-acyl chains in macrophages [S]
VZ Wall, S Barnhart, F Kramer, JE Kanter… - Journal of Lipid …, 2017 - ASBMB
Abstract Acyl-CoA thioesterase 7 (ACOT7) is an intracellular enzyme that converts acyl-
CoAs to FFAs. ACOT7 is induced by lipopolysaccharide (LPS); thus, we investigated
downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings
in myeloid cells. Enzymatic thioesterase activity assays in WT and ACOT7-deficient
macrophage lysates indicated that endogenous ACOT7 contributes a significant fraction of
total acyl-CoA thioesterase activity toward C20: 4-, C20: 5-, and C22: 6-CoA, but contributes …
CoAs to FFAs. ACOT7 is induced by lipopolysaccharide (LPS); thus, we investigated
downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings
in myeloid cells. Enzymatic thioesterase activity assays in WT and ACOT7-deficient
macrophage lysates indicated that endogenous ACOT7 contributes a significant fraction of
total acyl-CoA thioesterase activity toward C20: 4-, C20: 5-, and C22: 6-CoA, but contributes …
