Mast cells are known to be the central effector cells in the early phase and important in the
late phase of IgE-mediated allergic inflammatory reactions [1]. Mast cells can be activated to
secrete diverse preformed mediators and de novo synthesized lipid mediators and cytokines
after cross-linking of Fc3 receptor (Fc3R) I–bound IgE with multivalent antigen [2]. The wide
range of the biologic effects of the various mediators accounts for the role of mast cells in the
induction of acute allergic responses as well as in the development of chronic allergic …