An in situ molecular signature to predict early recurrence in hepatitis B virus-related hepatocellular carcinoma
J Xu, T Ding, Q He, XJ Yu, WC Wu, WH Jia, JP Yun… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: To develop an in situ molecular signature to predict postsurgical
recurrence in hepatocellular carcinoma (HCC) patients. METHODS: Immunohistochemistry
was performed using tissue microarrays containing both tumoral and peri-tumoral regions of
the advancing tumor edge from 336 HCC patients (289 were positive for hepatitis B virus)
who underwent curative resection. Forty-nine variables were analyzed in the training set (n=
151) using support vector machine and stepwise algorithms to develop a classifier to predict …
recurrence in hepatocellular carcinoma (HCC) patients. METHODS: Immunohistochemistry
was performed using tissue microarrays containing both tumoral and peri-tumoral regions of
the advancing tumor edge from 336 HCC patients (289 were positive for hepatitis B virus)
who underwent curative resection. Forty-nine variables were analyzed in the training set (n=
151) using support vector machine and stepwise algorithms to develop a classifier to predict …
