Development of a mouse model of ischemic osteonecrosis
N Kamiya, R Yamaguchi, O Aruwajoye… - Clinical Orthopaedics …, 2015 - journals.lww.com
Background Availability of a reliable mouse model of ischemic osteonecrosis could
accelerate the development of novel therapeutic strategies to stimulate bone healing after
ischemic osteonecrosis; however, no mouse model of ischemic osteonecrosis is currently
available. Questions/purposes To develop a surgical mouse model of ischemic
osteonecrosis, we asked,(1) if the blood vessels that contribute to the blood supply of the
distal femoral epiphysis are cauterized, can we generate an osteonecrosis mouse model;(2) …
accelerate the development of novel therapeutic strategies to stimulate bone healing after
ischemic osteonecrosis; however, no mouse model of ischemic osteonecrosis is currently
available. Questions/purposes To develop a surgical mouse model of ischemic
osteonecrosis, we asked,(1) if the blood vessels that contribute to the blood supply of the
distal femoral epiphysis are cauterized, can we generate an osteonecrosis mouse model;(2) …