Systematic review of ophthalmate as a novel biomarker of hepatic glutathione depletion
SAWG Dello, EPJG Neis, MC de Jong, HMH van Eijk… - Clinical nutrition, 2013 - Elsevier
BACKGROUND: Sustainability of hepatic glutathione (GSH) homeostasis is an important
cellular defense against oxidative stress. Therefore, knowledge of liver GSH status is
important. However, measurement of plasma GSH and tissue is difficult due to its instability.
Alternatively, ophthalmate (OPH), an endogenous tripeptide analog of GSH, has been
suggested as a potential indicator to assess GSH depletion. AIM: To provide an overview of
present knowledge with respect to the usefulness of OPH as a biomarker for oxidative stress …
cellular defense against oxidative stress. Therefore, knowledge of liver GSH status is
important. However, measurement of plasma GSH and tissue is difficult due to its instability.
Alternatively, ophthalmate (OPH), an endogenous tripeptide analog of GSH, has been
suggested as a potential indicator to assess GSH depletion. AIM: To provide an overview of
present knowledge with respect to the usefulness of OPH as a biomarker for oxidative stress …
