Autoimmune arthritis: the interface between the immune system and joints
N Komatsu, H Takayanagi - Advances in immunology, 2012 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic inflammation
and synovial hyperplasia in the joints that ultimately lead to cartilage and bone destruction.
A wealth of research has shown that CD4+ T cells, especially IL-17 producing helper T
(Th17) cells, play an important role in RA development. However, it still remains to be
clarified how the systemic immune response results in the local joint disorders. Studies on
animal models of RA have shed light on the importance of the interaction between immune …
and synovial hyperplasia in the joints that ultimately lead to cartilage and bone destruction.
A wealth of research has shown that CD4+ T cells, especially IL-17 producing helper T
(Th17) cells, play an important role in RA development. However, it still remains to be
clarified how the systemic immune response results in the local joint disorders. Studies on
animal models of RA have shed light on the importance of the interaction between immune …