[HTML][HTML] TNFα-exposed bone marrow-derived mesenchymal stem cells promote locomotion of MDA-MB-231 breast cancer cells through transcriptional activation of …

SY Shin, JS Nam, Y Lim, YH Lee - Journal of Biological Chemistry, 2010 - ASBMB
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are often recruited to solid
tumors, integrate into the tumor stroma, and contribute to tumor development. TNFα is a
major inflammatory cytokine present in the tumor microenvironment and has a profound
influence on the progression of tumor development. This study was aimed to investigate the
role of BM-MSCs in tumor promotion in response to TNFα. Quantitative real-time PCR arrays
show that diverse cytokines/chemokines were induced in TNFα-treated BM-MSCs; in …