Immunology of gut-bone signaling

FL Collins, JD Schepper, ND Rios-Arce… - Understanding the Gut …, 2017 - Springer
FL Collins, JD Schepper, ND Rios-Arce, MD Steury, HJ Kang, H Mallin, D Schoenherr…
Understanding the Gut-Bone Signaling Axis: Mechanisms and Therapeutic Implications, 2017Springer
In recent years a link between the gastrointestinal tract and bone health has started to gain
significant attention. Dysbiosis of the intestinal microbiota has been linked to the pathology
of a number of diseases which are associated with bone loss. In addition modulation of the
intestinal microbiota with probiotic bacteria has revealed to have both beneficial local and
systemic effects. In the present chapter, we discuss the intestinal and bone immune systems,
explore how intestinal disease affects the immune system, and examine how these …
Abstract
In recent years a link between the gastrointestinal tract and bone health has started to gain significant attention. Dysbiosis of the intestinal microbiota has been linked to the pathology of a number of diseases which are associated with bone loss. In addition modulation of the intestinal microbiota with probiotic bacteria has revealed to have both beneficial local and systemic effects. In the present chapter, we discuss the intestinal and bone immune systems, explore how intestinal disease affects the immune system, and examine how these pathologic changes could adversely impact bone health.
Springer