Nitrite-NO bailout for a NOS complex too big to fail
MT Gladwin, J Tejero - Nature medicine, 2011 - nature.com
Nature medicine, 2011•nature.com
Cellular production of nitric oxide (NO) by nitric oxide synthase (NOS) in the face of limiting
pools of arginine requires the intracellular citrulline-to-NO pathway, catalyzed by the enzyme
argininosuccinate lyase (ASL). People with the urea cycle disorder argininosuccinic
aciduria, caused by a deficiency of ASL, have systemic NO deficiency, which can be rescued
by the use of an alternative, NOS-independent, nitrite-to-NO pathway.
pools of arginine requires the intracellular citrulline-to-NO pathway, catalyzed by the enzyme
argininosuccinate lyase (ASL). People with the urea cycle disorder argininosuccinic
aciduria, caused by a deficiency of ASL, have systemic NO deficiency, which can be rescued
by the use of an alternative, NOS-independent, nitrite-to-NO pathway.
Cellular production of nitric oxide (NO) by nitric oxide synthase (NOS) in the face of limiting pools of arginine requires the intracellular citrulline-to-NO pathway, catalyzed by the enzyme argininosuccinate lyase (ASL). People with the urea cycle disorder argininosuccinic aciduria, caused by a deficiency of ASL, have systemic NO deficiency, which can be rescued by the use of an alternative, NOS-independent, nitrite-to-NO pathway.
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