Partitioning-defective 1a/b depletion impairs glomerular and proximal tubule development
O Akchurin, Z Du, N Ramkellawan, V Dalal… - Journal of the …, 2016 - journals.lww.com
The kidney is a highly polarized epithelial organ that develops from undifferentiated
mesenchyme, although the mechanisms that regulate the development of renal epithelial
polarity are incompletely understood. Partitioning-defective 1 (Par1) proteins have been
implicated in cell polarity and epithelial morphogenesis; however, the role of these proteins
in the developing kidney has not been established. Therefore, we studied the contribution of
Par1a/b to renal epithelial development. We examined the renal phenotype of newborn …
mesenchyme, although the mechanisms that regulate the development of renal epithelial
polarity are incompletely understood. Partitioning-defective 1 (Par1) proteins have been
implicated in cell polarity and epithelial morphogenesis; however, the role of these proteins
in the developing kidney has not been established. Therefore, we studied the contribution of
Par1a/b to renal epithelial development. We examined the renal phenotype of newborn …